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KMID : 0043320160390070970
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Archives of Pharmacal Research
2016 Volume.39 No. 7 p.970 ~ p.977
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Profile of disposition, tissue distribution and excretion of the novel anti-human immunodeficiency virus (HIV) agent W-1 in rats
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Lu Ying Yuan
Wang Xiao Wei
Wang Xin
Dai Wen Bing
Zhang Qiang
Li Pu
Lou Ya Qing
Lu Chuang
Liu Jun Yi
Zhang Guo Liang
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Abstract
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The purpose of this study was to characterize the disposition, distribution, excretion and plasma protein binding of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1) in rats. Concentrations of W-1 within biological samples were determined using a validated high performance liquid chromatography method. The plasma protein binding of W-1 was examined by equilibrium dialysis method. After oral administration of W-1 (50, 100 and 200 mg/kg, respectively) in self-microemulsifying drug delivery system formulation, the pharmacokinetic parameters of W-1 were as follows: the peak plasma concentrations (Cmax) were 0.42, 1.50 and 2.55 μg/mL, the area under the curve (AUC0?t) were 0.89, 2.27 and 3.96 μg/h mL and the plasma half-life (t1/2) were 5.15, 3.77 and 3.77 h, respectively. Moreover, the prototype of W-1 was rapidly and extensively distributed into fifteen tissues, especially higher concentrations were detected in intestine, stomach and liver, respectively. The plasma protein binding of W-1 in rat, beagle dog and human were in the range of 97.96?99.13 %. This study suggested that W-1 has an appropriate pharmacokinetics in rats, such as rapid absorption, moderate clearance, and rapid distribution to multiple tissues. Those properties provide important information for further development W-1 as an anti-HIV-1 drug candidate.
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KEYWORD
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6-Benzyl-1-benzyloxymethyl-5-iodouracil (W-1), Disposition, Tissue distribution, Excretion, Plasma protein binding, Rat
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